Fasting & Mtor Cell division & replication

This applies to not only reducing the amount of times the main meals are fed, but also includes treats. Anytime food is ingested we are stimulating MTOR in the body

Fasting a dog can have a profound effect on their health, and this is a topic that we might want to especially pay attention to in cancer dogs. Here’s what Joseph Scott Powell from Vibrant K9 had to say about feeding 1x a day

” So, the issue is how often do you want to stimulate cell growth and how often do you want to stimulate cell repair (autophagy) and damaged cell suicide (apoptosis) all while keeping muscle wasting (sarcopenia) in check. It’s a balance, but a even more sensitive balance in dogs or humans with cancer. MTOR (Mammalian Target of Rapamycin) is the nutrient sensor for protein. MTOR is stimulated by protein (also insulin and IGF1 but we shouldn’t need to talk about carbs and cancer in this group), But mainly by protein. MTOR stimulates cell division and replication, which is a good thing when you are growing but a really bad thing when you have cancer and you want to stop cell division and replication. So, let’s just stop giving protein to anyone with cancer and we are done. That won’t work because that will induce Sarcopenia and eventually death (seems like a bad side effect). So, what do we do? We get the patient to consume as little protein as is possible and still stave off Sarcopenia. By the way Ketosis has a huge muscle sparing effect so this puts the patient in a much better position to decrease muscle wasting and actually increase muscle mass. We also stimulate MTOR as few times in a day or week as possible. Same calories and Macros but if you spread them out 20 times in a day you stimulate MTOR 20 times a day but if you feed once a day or once every other day the patient gets the protein they need but stimulate MTOR less often. By the way the more you fast (intermittent or long term) the more you stimulate Apoptosis and Autophagy.”

Dr.Becker talks about fasting in the beginning of this video and then goes on to talk about ketosis:


More detail can be learned about this from Dr. Ron Rosedale in the video below
the Mtor talk is around the 24 min mark. but I recommend watching the entire video!

Now, it’s important to note that all dogs are different! some people in our group have reported having issues with their dogs hitting ketosis when they only fed 1x a day and they weren’t able to get into ketosis until they switched to 2x a day.